CBD Oil Side Effects
CBD Benefits & FAQs

CBD Oil Side Effects: What to Know Before You Try CBD Oil

Reviewed by Lisa Blohm, PhD, MSN, RN


CBD oil has been the talk of the town, gaining widespread attention for its numerous benefits. We’re excited about it because there is so much CBD oil can do! 

But as the saying goes, nothing’s perfect.

Quick Takeaways:

  • CBD oil has anti-inflammatory properties that can help alleviate chronic pain conditions, offering a natural alternative to traditional pain medications.
  • Generally, CBD oil has minimal side effects.
  • Overdosing on CBD oil is highly unlikely.
  • Interaction with other medications is possible but rare.
  • CBD oil generally doesn’t make you feel spacey

Benefits of CBD Oil

The therapeutic benefits of CBD (Cannabidiol) have garnered significant attention in recent years, with a growing body of scientific research supporting its potential advantages. Many users and studies report that CBD can effectively alleviate chronic pain conditions, reduce anxiety and stress, and improve sleep quality. In certain cases, it has shown promise in treating more severe conditions like epilepsy, with some patients experiencing a reduction in seizure frequency.

One of our commenters, Paul Turner, praises CBD for helping him with shoulder bursitis and even allowing him to discontinue his use of over-the-counter pain relievers. He says,

“I started to take CBD after I had a hard time sleeping due to bursitis in the shoulder. My trips to physical therapy only aggravated the pain issues from inflammation. My doctor and PT prescribed ibuprofen but when I used their prescribed dosage, it caused me more gastric problems than normal. Since using CBD sublingual at 5 drops of 300 mg at night, it seemed to help me get through the night and I stopped completely the use of over the counter pain relievers. An added unexpected benefit of daily nightly CBD use, was that my Gerd symptoms (that I had for years) disappeared and allowed me to stop taking Prilosec daily. For pain during the day, I use CBD as needed. I think CBD is a great natural alternative to pills.”

Does CBD Oil Make You Feel Spacey?

Many users report feeling relaxed or calm after taking CBD oil. However, some individuals report experiencing a “spacey” or disoriented feeling. It’s important to note that CBD is non-psychoactive, meaning it won’t make you “high.” However, the sensation of feeling “spacey” is subjective and may differ from person to person. If you’re concerned about this, start with a low dose and monitor your reactions.

More on What You Need to Know About CBD Oil Side Effects

Let’s set the record straight: CBD oil is generally considered to be a “safe substance,” even by stringent government standards. 

In fact, whole cannabis, from which CBD is derived, is also seen as an extremely safe drug. It’s virtually impossible for an adult human to ingest a fatal dose, although excessive use can certainly make you feel uncomfortable.

However, our bodies can react differently to substances. So while CBD has a commendable safety profile, individual responses can vary. 

Here, we’re diving into the commonly reported side effects, as backed by scientific research and consumer testimonials. Even without the official “a-okay”, the feedback on this supplement is overwhelmingly positive, affirming that CBD is a remarkably safe supplement with minimal side effects.

Dry Mouth Concerns with CBD Oil 

Dry mouth is a commonly reported side effect when using CBD oil. While it’s mostly a minor inconvenience that will likely make you drink a bit more water, it’s worth understanding the science behind it. Research indicates that the endocannabinoid system’s CB1 and CB2 receptors, found in saliva glands, could be responsible for this effect. When activated, these receptors may reduce saliva production, causing dry mouth.

Blood pressure and CBD Oil

While CBD oil is generally well-tolerated, it can lead to a slight drop in blood pressure for some people, particularly when taken in high doses. You may experience mild lightheadedness for a few minutes as your body adjusts. Importantly, if you have a history of blood pressure issues or are on medication for it, consult your healthcare provider before incorporating CBD oil into your routine.


Some individuals may experience a brief sensation of lightheadedness or dizziness after taking CBD oil. This is often linked to the minor blood pressure drop discussed earlier, but it can also occur independently. The feeling is usually temporary and can be likened to the dizziness you feel when standing up too fast. If you encounter this, taking a moment to sit down to enjoy a beverage or a light snack can typically alleviate the sensation.”

CBD Oil and Nausea: A Double-Edged Sword?

While CBD oil is frequently used to combat nausea, some reports we’ve heard and read say that some people experience stomach discomfort after ingesting it. A handful of our customers have experienced this, but it is very uncommon. If you do experience mild nausea, it generally passes swiftly and can often be managed by lowering your CBD dosage or taking your CBD with food.

Does CBD Oil Cause Gas?

In addition to nausea, some users are concerned about the possibility of experiencing gas after taking CBD oil. Although this side effect is less commonly reported, it does appear in some testimonials. Just like with nausea, these reports are not yet backed by scientific studies. If you find that CBD oil is causing you gastrointestinal discomfort, including gas, consider adjusting your dosage or consulting your healthcare provider.

Drowsiness and CBD Oil: A Timing Matter

CBD oil’s effects can vary depending on the dosage. At low doses, it’s known for inducing relaxation and reducing pain or anxiety—factors that could contribute to sleep issues. However, at higher doses, CBD oil can cause drowsiness. It is often used as a sleep aid. So, if you find that it makes you sleepy, you may want to adjust the timing of your dosage. For instance, consider taking it later in the day rather than before driving or operating machinery. Also, remember that the effects may take a few hours to set in.

Increased tremors in Parkinson’s disease

For those with Parkinson’s Disease, caution is advised when considering CBD oil. Initial studies indicated that high doses of CBD could exacerbate muscle tremors related to the condition. However, more recent studies suggest that low doses could be both safe and beneficial. Given the conflicting evidence, it’s essential to consult with your healthcare provider for personalized advice before trying CBD oil, especially if you’re already managing a medical condition like Parkinson’s.

Headaches and CBD Oil: Quality Matters

While many find relief from headaches and migraines using CBD oil, some report headaches as a side effect. If you fall into the latter group, the culprit may be the quality of your CBD oil or the presence of solvents like ethanol and isopropanol, to which some people are sensitive. 

Switching to a higher-quality, hemp-based CBD oil may resolve this issue. Keep in mind that individual reactions can vary, so it’s possible that CBD just may not be the right solution for you. On the scientific front, ongoing research continues to affirm the safety and potential benefits of CBD oil, despite regulatory challenges.

Drugs to Avoid When Taking CBD Oil

While CBD oil is generally considered safe, it can interact with certain medications by affecting liver enzymes responsible for drug metabolism. In simpler terms, high doses of CBD could temporarily disable these enzymes, altering how your medications work.

This interaction is similar to why you’re advised not to eat grapefruit with certain medications; some substances just don’t mix well.

So, if you’re on any prescription drugs, such as blood thinners, antidepressants, anti-seizure drugs, blood pressure medications, or others, consult your pharmacist or primary care physician before adding CBD oil to your regimen to prevent potential complications.

Frequently Asked Questions

To recap, here are the questions we are asked most commonly about CBD Oil:

Does CBD Oil Make You Feel Spacey?

No, CBD oil generally does not make you feel “spacey.” It is non-psychoactive, unlike its counterpart THC. However, some users have reported feeling slightly different after consumption, which could vary from person to person.

What Are the Most Common Side Effects of CBD Oil?

The most commonly reported side effects include dry mouth, a slight drop in blood pressure, and mild dizziness. Most of these are temporary and quickly resolve on their own.

Does CBD Oil Cause Gas or Other Gastrointestinal Issues?

While CBD oil is often used to aid digestion and alleviate nausea, some users have reported stomach discomfort or gas.

Can CBD Oil Interact with Other Medications?

Yes, CBD oil can interact with certain medications. If you are taking any prescription medications, we advise you to consult with your pharmacist or prescribing physician.

How Do I Choose the Right CBD Oil?

Look for a high-quality product that contains at least 50% CBD and minimal THC (less than 0.03%). Verify that it has been manufactured in regions with strict quality regulations, like Canada or the USA. For more, visit our shop.

Can CBD Oil Cause Headaches?

While CBD oil is often used to relieve headaches, some users have reported headaches as a side effect. This is usually linked to the quality of the CBD oil or its compatibility with the individual.

Choosing the Right CBD Oil

To experience the full benefits of CBD oil, selecting a high-quality product is crucial. While we’ve carefully vetted the brands available in our online shop, it’s essential to know what to look for, especially when buying online.

Here are some key points to consider:

1. Prioritize purity: Opt for products that contain at least 50% CBD and minimal THC (less than 0.03%).

2. Verify the origin: We recommend you stick to CBD oil manufactured in Canada or the USA, where strict regulations help ensure quality.

3. Avoid bargain hunting: Quality CBD oil is an investment in your health. While it might be tempting to go for cheaper options, higher quality usually comes at a higher price — and it’s worth it.

Now that you’re informed about the key aspects of selecting CBD oil, you’re better equipped to make a wise choice. 

For additional insights, feel free to explore our extensive library of CBD research studies or reach out via LiveChat for personalized recommendations from our certified Wellness Consultants.

Rynn Jacobson is Content Marketing Director. She's passionate about educating people on natural and alternative health and wellness options. Her favorite ways to stay healthy are drinking herbal tea and hiking in the mountains.


90 comments on “CBD Oil Side Effects: What to Know Before You Try CBD Oil

  1. Pollen on

    I’m sensitive to CBD and it causes me severe migraines. Your article blames the quality of my CBD products but I got them from licensed producers heavily regulated by my government. There is no solvent left within the oil by the time it is done, because testing confirms as much or else it cannot be used within my legal medicinal cannabis system that exists within my country. So I want to say, that yes, CBD can cause headaches and migraines for the same reason it helps with them. Any substance that affects an area of the body can either improve it or make it worse because it is interacting with that part of the body and everyone responds differently to substances. I know I have a CBD sensitivity, I also know THC is a better analgesic and anti-inflammatory thanks to many studies done within my country that prove as much. So I am lucky that I am able to access both substances as needed in my country and I am aware not everyone had that option. Be honest that some people are sensitive to it and it does give some a worsening of symptoms because everyone is different and everyone should do what is best for them in their individual circumstances.

  2. Lisa Garcia on

    I started taking CBD oil on a Thursday evening, was in the bathroom most of Friday. Stomach ache all day Saturday and more bathroom issues, by Sunday morning I was bloated, nauseated and more frequent bathroom trips. I did not take Sunday evening dose. But it is not Wednesday and I still have bloating, nausea, stomach aches and more bathroom trips than normal. How long before these symptoms subside. I do have a slower digestive tract. I have increased my fluid intake and added gatorade to hopefully flush this out of me.

    • Rynn Jacobson on

      Happy Monday, I hope your week is off to a smiling and sunny start.

      I’m sorry to hear about your unbalance within your digestive tract! We help clients digest issues like this almost every day. It is a bit unusual that CBD, even after just a few doses, would do this to the digestive tract.
      You might be sensitive to the carrier oil within the product itself. Usually, this is MCT oil (healthy fats for coconut oil) or hemp seed oil (also healthy fats from the hemp plant itself).

      If this is the case, you are on the right track for resetting the gut. Lots of water, minerals, and sleep!
      If you need an extra hand with detoxing, we have a few awesome recommendations as well!

      Also, there are many different profiles of CBD for your support — hopefully, one of which won’t affect you so intensely! Let us know if you have any other questions on your goals and we can recommend a far better fit for your success. Click the LiveChat button on our site in the bottom right hand corner and one of our Wellness Consultants can help you out in no time.

      Enjoy your week and thanks for letting us know!

  3. Samantha on

    I have Narcolepsy, and decided to try a CBD/THC oil. I have never had any good experiences with THC in the past, due to the psychoactive affect it always had on me. Therefore I’ve always avoided it due to it causing everything from mild paranoia to horrifying hallucinations.
    However, in an effort to try to find a more natural solution to taking strong and addictive sleep medication, I recently began taking an average 18:1 ratio (18 parts CBD, 1 part THC). Or a beverage with a 4mg CBD, 2mg THC. INever more than 4mg at the most of THC at any time. It was working well for me! I recently cut out the THC for a short period while looking for a new job, and switched solely to CBD oil only. After a few days of that, I began experiencing severe stomach pain, it first felt like severe menstrual cramps and then morphed into feeling like I was punched in the gut, then proceeded to experience everything from cramping to bloating, gas, diarrhea, sharp and burning intestinal pain etc.
    I switched brands, which helped for a few days, but the pain has returned. I’m miserable and horribly uncomfortable in the mornings and then again in the early afternoon, lasting the rest of the day.
    I’m confused as to whether this is a result of the CBD oil itself, or is from stopping it? Either way, I haven’t had much nausea, only severe stomach and lower back pain.
    Do I stop it completely or continue to take it? I cannot seem find any balance with either option?

    • Ross Maly on

      Hi Samantha, thanks for reaching out! That sounds pretty intense & I’m sorry you’re experiencing this. At this point I’d suggest refraining from any CBD/THC mixtures for at least 1 week to give your system a bit of a reset. There are many other supportive supplements when dealing with narcolepsy such as omega 3 fatty acids, a high quality multivitamin & especially vitamin D! If you’d like to try the CBD/THC again make sure you’re getting it from a high quality/trustable brand. Here is the one we’ve seen lots of great results with over the years – click here

      Please reach out if you have further questions! We want to do our best to support you and your health. Best wishes.

      Wellness Consultant
      [email protected]

  4. Pam on

    Hi! The Cbd I’m using is make me nauseated and dizzy. I do think it helps my pain but I just want to sleep. Since it daytime and have so much that needs to be done I’m at a loss. Not helps the sciatic pain but the other things make me feel like I’m getting vertigo. I have Hasimoto and take quite a few supplements. Only used recommended dosag e in the 100mg bottle the first day and half of that the second day. Not sure Cbd is for me?


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