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Thorne Research

Thorne Research Methyl-Guard Plus Capsules

$6200

Pickup available at Fitchburg

Usually ready in 4 hours

90 capsules

Enjoy healthy cognitive and cardiovascular function with Thorne Research Methyl Guard-Plus, an advanced formula that helps maintain DNA methylation.*

  • Supports healthy cognitive function.*
  • Supports cardiovascular health.*
  • Contains active B vitamins
  • Helps maintain homocysteine levels already within the normal range.*
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Thorne Research Methyl-Guard Plus


It can be a very difficult task to get the right amount of nutrients for methylation even with a healthy diet. Luckily, there’s no need to worry about that when you have Thorne Research Methyl-Guard Plus, a supplement designed to promote healthy DNA methylation.*


What is methylation? How does it help you? Methylation is when a methyl group is added to the cytosine in your DNA. Methylation levels peak when you’re an infant and drop as you grow older — a common marker associated with aging. Methylation plays an important role in normal gene expression and cellular function.* But, that’s not all. It also helps keep homocysteine levels in check, directly contributing to cardiovascular function, cognitive health, hormonal balance, and more!*


Luckily, Thorne Research Methyl-Guard Plus is here to help provide the key nutrients you need to keep your methylation levels going strong. This advanced formula is fortified with vitamin B vitamins, along with carefully selected ingredients that are free of common allergens like dairy, soy, and gluten. Support healthy DNA methylation and cellular function with Thorne Research Methyl-Guard Plus.*

Suggested Use: Take 1-3 capsules daily or as recommended by your health professional.

Cautions: Keep out of the reach of children. Consult a physician before taking this product if you are pregnant, nursing, taking any medications, or have a medical condition. 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

Allergy Warning: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

Questions? We’ve got answers! Reach out to our support team for help.
Serving Size: 3 Capsules

Servings Per Container: 30

Ingredients:

  • Riboflavin (As Riboflavin 5'-Phosphate Sodium)

  • Vitamin B6 (As Pyridoxal 5'-Phosphate)

  • Folate (3 mg As L-5-Methyltetrahydrofolate† From L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)

  • Vitamin B12 (As Methylcobalamin)

  • Betaine Anhydrous (Trimethylglycine)

Other Ingredients: Hypromellose (Derived From Cellulose) Capsule, Calcium Citrate, Calcium Laurate

FAQs About Thorne Research Methyl-Guard Plus Capsules

Q: What does Methyl-Guard Plus help with? A: It’s mainly used for methylation support, especially for homocysteine, brain function, and cardiovascular health. It uses active B vitamins plus betaine anhydrous, which is trimethylglycine, to help those methylation pathways work properly.

Q: Why does this one use methylfolate instead of regular folic acid? A: Because it’s already in the active form. You get 3 mg of L-5-methyltetrahydrofolate per 3 capsules, so some people go with it when they don’t want plain folic acid.

Q: How many capsules should I take per day? A: One to three daily. I’d start with 1 capsule and see how you do, since a full serving is 3 capsules.

Q: Does it have methylated B12 and B6? A: Yes. It uses methylcobalamin for B12 and pyridoxal 5'-phosphate for B6, plus riboflavin 5'-phosphate for B2, so you’re getting the active forms people usually look for.

Q: My doctor said to watch my homocysteine. Is this the kind of formula people use for that? A: Yes, that’s a common reason people pick it. It has methylfolate, methylcobalamin, P5P, riboflavin 5'-phosphate, and trimethylglycine, which are the ingredients people usually look for when homocysteine is the concern.

Q: Should I take it with food? A: You can, and a lot of people do because B vitamins can feel a little strong on an empty stomach. Earlier in the day usually works better if you’re sensitive to energizing supplements.

Q: Are there any medication concerns with this one? A: Yes, a couple. If you’re on methotrexate cancer therapy, don’t use 5-MTHF unless your doctor specifically tells you to. And if you’re pregnant, nursing, or taking any medications, I’d check with your doctor before starting it.

At The Healthy Place, we strive for accuracy in our product images and information. However, manufacturers may make changes to product packaging or ingredients that are not yet reflected on our site. We recommend that you read the labels, warnings, and directions on purchased products before use and not rely solely on the information provided by The Healthy Place.

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